제품소개
Sermorelin peptide is an acetylated GRF (1-29) also called Sermorelin Acetate, a high-purity synthetic peptide analog of growth hormone-releasing hormone (GHRH) found in humans. Structurally, it comprises the first 29 amino acid residues of the natural GHRH sequence (44-amino-acid GHRH sequence), which was determined to be a minimal bioactive fragment that fully binds and activates human GHRH receptors. This peptide is much more stable, less costly to produce and a reproducible biological activity compared with full-length GHRH (23) having a chemical structure of 3357.92 g/mol. Sermorelin is available in bulk in clinical and laboratory research, and it essentially produces GH secretagogues by exerting a stimulating effect on the activity of the anterior pituitary where GH release occurs naturally as an endogenous secretion (via a pulsatile mechanism) without addressing what could be adverse feedback inhibition risks associated with exogenous failures to provide ideal supplementation for GH. It has emerged as a central research instrument in the fields of endocrinology, metabolic physiology, and aging-related biomedical research.
제품 연구 배경
Sermorelin was discovered as part of peptide research in the 1980s, when scientists first isolated and sequenced human GHRH from endogenous sources. Pharmacological studies demonstrated that the initial 29 amino acid N-terminal [1-29] fragment of GHRH retained full physiological activity, whilst downstream C-terminal fragments had no significant effect on receptor binding and signal transduction. This important discovery set the stage for the development of Sermorelin. This was followed by a number of clinical and preclinical trials in subsequent decades that confirmed its safety and efficacy in governing the GH axis. After gaining FDA approval for clinical adjuvant diagnosis and growth hormone deficiency investigations, Sermorelin was slowly removed from commercial clinical usage due to market adjustment needs instead of some sort of parameters rather than safety problems. To date, one of the most investigated GHRH analogs with extensive published literature supporting its use in elucidating growth regulation, metabolic homeostasis, and hormonal changes accompanying aging.
규정 준수 & 연구 면책조항
This peptide product of Sermorelin is intended solely for use in scientific laboratory research and academic study. Human clinical use, medical diagnosis, treatment or personal consumption is not approved. The product meets the internationally accepted specifications for peptide research reagent production and regional laboratory material management regulations. The products and data that you have provided in this section on the site are for educational writing or experimental testing purposes only and not intended for commercial medical use or non-label use. It is incumbent on researchers and purchasers to comply fully with local laws, regulations and institutional laboratory management requirements. We disclaim all liabilities arising from any unauthorized clinical application, improper use or unlawful operation of the product. No product description and research data represent or guarantee any medical efficacy or therapeutic effect.
실험실 응용
Sermorelin peptide is widely used as an essential research reagent in many modern biomedical laboratories with standardized applications for various research directions. Firstly, it has been extensively applied in the study of GH axis physiology which enables scholars to analyze the regulatory mechanism of hypothalamic-pituitary growth hormone secretion and explore endogenous hormones constituting a feedback regulation loop between various levels of intra- and extra-brain nuclei. 둘째, it has a role in research of growth hormone deficiency and developmental disorders, providing experimental data for in-depth studies on the pathogenesis and intervention strategies of abnormal stature. Third, it is used in the field of aging biology to determine whether age-related decline in GH secretion contribute to metabolic aging and/or the loss of organ function or body composition. Sermorelin is also used in experiments to detect pituitary reserve function, and for studies of metabolic regulation using in vitro and/or animal models which assist researchers when validating the effect of peptide intervention on cell growth activity, lipid metabolism and energy balance. It has biological effects that are stable and repeatable, which ensures high reliability for experimental data.
품질 표준
We follow international standards for peptide production and determination to supply high quality options for research use only. Your product has a normal molecular formula of C149H246N44O42S and an amino acid sequence as follows, with complete concordance to the authoritative GRF (1-29) specification. Immune defence efficacy for all batches: HPLC-tested with guaranteed purity - ≥ 98% (free from irrelevant peptide fragments, impurities and heavy metal residues.) The first verification of molecular weight and structure provides the verifying point for every batch block through mass spectrometry (MS). It is produced at a GMP compliant clean laboratory, supplied in standardised lyophilized powder packaging to prevent degradation and contamination. Before delivering, it is stringently checked for microbial limit testing, endotoxin detection and stability testing. With each batch, a full quality inspection report — purity, structure verification results and safety test indicators are all provided so that you can guarantee experimental consistency and repeatability.
자주 묻는 질문 (자주 묻는 질문)
1분기: What are its 3 main benefits compared to full-length GHRH? 답변 1: Sermorelin is a minimal active fragment of GHRH with better chemical stability, longer half-life of degradation and more stable biological activity in experiment. As it is less expensive, more stable and easier to store and transport than full-length GHRH, it is more appropriate for long-term use and large-scale laboratory studies.
2분기: Under what conditions should you store Sermorelin peptide?
Q2 — How do you store the lyophilized powder? A2: The lyophilized powder should be dry, dark and steriled in -20 °C and avoid repeated freezing–thawing. After reconstitution with sterile water, it should be used as soon as possible and can only be stored at a low temperature in refrigerator for a short time (i.e., activity loss).
3분기: Is it appropriate for in vivo and in vitro experiments?
A3: 예. It has stable biological activity and low endotoxin, which meets the requirement of mainstream biomedical experiments: Our high-purity Sermorelin can be applied to in vitro cell-level mechanism research experiments and in vivo animal model experimental research through various routes of administration.
4분기: Is your product for use in human medicine?
A4: Absolutely not. 부인 성명: This product is a professional laboratory research reagent only, not a pharmaceutical product. It does not allow for any human body injection, treatment or clinical auxiliary application.
10 펩타이드에 관한 일반적인 FAQ
- 펩타이드란??
답변: 펩타이드는 펩타이드 결합으로 서로 연결된 아미노산의 짧은 사슬입니다.. 단백질보다 크기가 작고 인체에 더 쉽게 흡수됩니다., 생물학적 유기체의 기본 기능 물질로 작용.
- 펩타이드와 단백질의 차이점은 무엇입니까?
답변: 핵심 차이점은 분자 길이와 구조에 있습니다.. 펩타이드는 짧은 아미노산 사슬입니다. (일반적으로 2~50개의 아미노산으로 구성), 단백질은 길지만, 안정적인 3차원 구조를 지닌 복잡한 아미노산 사슬. 펩타이드는 단백질보다 투과성이 강하고 흡수 효율이 빠릅니다..
- 주요 유형의 펩타이드는 무엇입니까??
답변: 펩타이드는 주로 아미노산의 수에 따라 분류됩니다.: 디펩티드, 트리펩타이드, 올리고펩타이드 (2–10개의 아미노산) 및 폴리펩티드 (10–50개 아미노산). 또한 공급원에 따라 천연 펩타이드와 합성 펩타이드로 나눌 수 있습니다..
- 펩타이드의 생물학적 기능은 무엇입니까?
답변: 펩타이드는 다양한 생물학적 활동을 가지고 있습니다., 인간의 신진 대사 조절을 포함하여, 면역 기능 개선, 세포 복구 촉진, 항산화, 노화 방지, 그리고 호르몬 수치 조절. 그들은 신체의 주요 신호 분자 및 조절 요인으로 작용합니다..
- 펩타이드는 인간이 사용하기에 안전한가요??
답변: 대부분의 천연 및 의학적으로 승인된 합성 펩타이드는 매우 안전합니다.. 그들은 작은 분자량을 가지고 있습니다, 낮은 독성, 그리고 몸에 축적되지 않습니다. 하지만, 표준화되지 않은 고용량 펩타이드 제품이나 순수하지 않은 합성 펩타이드는 경미한 불편함을 유발할 수 있습니다..
- 펩타이드의 일반적인 응용 분야는 무엇입니까?
답변: 펩타이드는 다양한 분야에서 널리 사용됩니다.. 생물의학 분야, 내분비 및 면역 질환 치료 약물로 만들어집니다.; 화장품에서, 그들은 노화 방지 및 피부 회복에 사용됩니다.; 건강제품에, 체력을 향상시키기 위한 영양 보충제 역할을 합니다..
- 인체가 외인성 펩타이드를 직접 흡수할 수 있나요??
답변: 예. 흡수되기 전에 분해되어야 하는 단백질과 달리, 저분자 펩타이드는 높은 흡수율과 활용효율로 장관과 피부에 직접 흡수될 수 있습니다., 신체에 생물학적 효과를 빠르게 발휘할 수 있습니다..
- 합성 펩타이드는 무엇을 위해 사용됩니까??
답변: 합성 펩타이드는 인위적으로 맞춤화된 아미노산 사슬입니다.. 그들은 주로 과학 연구에 사용됩니다., 임상 약물 개발, 타겟 스킨케어 성분 생산, 그리고 정확한 영양보충, 일부 천연 펩타이드보다 더 높은 순도와 표적 활성을 가지고 있습니다..
- 펩타이드 제품에 부작용이 있나요??
답변: 표준 펩타이드 제품은 대부분의 사람들에게 뚜렷한 부작용이 거의 없습니다.. 개별 그룹에서는 신체적 차이나 과다 섭취로 인해 경미한 위장 불편감이나 피부 민감성이 나타날 수 있습니다.. 장기간 과도하게 사용하면 신체의 대사 균형이 깨질 수 있습니다..
- 콜라겐 펩타이드와 일반 펩타이드의 차이점은 무엇입니까?
답변: 콜라겐 펩타이드는 콜라겐에서 추출, 분해된 특정 형태의 기능성 펩타이드입니다., 주로 피부 보습을 목표로, 주름개선 및 관절관리. 일반 펩타이드는 면역, 대사 등 더욱 다양한 조절 기능으로 더 넓은 범위를 포괄합니다., 콜라겐 펩타이드는 보다 집중적인 스킨케어와 안티에이징 효과를 가지고 있습니다..
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