Generic Name and Brand Names: Kisspeptin. Also known as metastin (Kisspeptin-54) along with truncated versions – Kisspeptin-14 and Kisspeptin-10. It does not have any FDA-approved brands or formulations as it is mainly used as investigational peptide in preclinical and translational research.
Class of Drug: Naturally occurring G-Protein-Coupled Receptor (GPR54/KISS1R) Activator, Peptide that regulates Neuroendocrine System and Metabolism
Chemical Definition: Kisspeptin is a group of peptides which are modified artificially and biologically active neuropeptides derived from the KISS1 gene. The full-length version of kisspeptin, Kisspeptin-54 is made of 54 amino acids while the shorter version, Kisspeptin-10 consists of 10 amino acids and has the highest binding affinity with receptors. All versions of kisspeptin possess a C-terminal RF-amide motif that is essential for receptor activation. Synthetic kisspeptin is more stable in terms of enzymatic stability and half-life compared to its natural counterparts.
- Mechanism
1.1 Receptor Activation
Kisspeptin binds and activates KISS1R which is formerly known as GPR54 through being a GPCR (Gq/11) that is mainly expressed in the hypothalamuic neurons, pituitary gland and metabolic tissues. The binding of the receptors initiates the phospholipase C-beta process leading to formation of IP3 and DAG secondary messengers that result in increase of intracellular calcium and depolarization of the neuron. Through this sequence of operations, the functions of the hypothalamic-pituitary axis are properly performed without interaction with other metabolic receptors such as GLP-1 and melanocortin receptors.
Compliance & Research Disclaimer
Kisspeptin Peptide is for research use only and academic experimental purposes. It is not registered as a pharmaceutical drug, dietary supplement or an over-the-counter medicine and has no clinical use approval from the FDA, EMA or other regional medical regulatory body. The product cannot be used for human clinical diagnosis, treatment of disease, oral or intravenous administration as well as commercial off-label usage. All of the product details and research data is academic in nature and not intended as medical advice or to be construed as therapeutic claims. Local laws, institutional laboratory-management requirements, and ethical-research standards must be followed by all purchasers and researchers. We shall not be liable for any unauthorized illegal use, improper operation or non-research application of the product.
1.2 Metabolic and physical effects
It is recognized as the main regulator of reproduction neuroendocrine functions as well as having an impactful effect on the systemic metabolism.It alters the hypothalamic energy-sensing way to control the eating behavior, glucose metabolism, and fat metabolism. In animal studies, it boosts the sensitivity of insulin in peripheral tissues, facilitates the amount of glucose taken up by the body, and reduces the inflammation that leads to type 2 diabetes and obesity. Also, kisspeptin influence on the neuroendocrine activity prevents metabolic and hormonal changes caused by hypoxia in people suffering from the sleep apnea. It brings energy spending in line with fat accumulation and thus plays an important role in maintaining metabolic balance.
2.6. Therapeutic Uses (based on scientific research)
Kisspeptin has only been researched for preclinical purposes and does not have any approved therapeutic indications for people.
Type 2 Diabetes Mellitus Studies: Kisspeptin has been widely used for the research into neuroendocrine-related disorders caused by poor glucose control, insulin resistance, and metabolic problems associated with diabetes.
Obesity Studies: The drug has been applied for obesity research to find out how it influences people's eating behavior, energy spending, and metabolism of fatty tissues.
Obstructive Sleep Apnea Studies: Kisspeptin has been analyzed for its ability to normalize the neuroendocrine disorder caused by sleep apnea and restore glucose and fat metabolism in patients with sleep apnea.
- Basic Neuroendocrine Studies: Kisspeptin is used in studies on reproductive axis control and development of puberty.Dosage and Administration (Standard Laboratory Practices)
3.1 Method of Administration and Continuity
Subcutaneous route of administration and intracerebroventricular injection mode of administration represent the standard procedures in laboratories for animal studies. The subcutaneous method yields the desired results since the research is based on the principles of systemic metabolism; hence one-time administration can be adopted. In laboratory studies, administration is performed on daily basis for metabolic intervention purposes, or in some occasions the substance is administered on intermittent basis to study neuroendocrine system.
3.2 Dose Titration Schedule
The maximum dose of KISS1R can be administered daily by titration of doses; thus in the case of preclinical research in animals, the initial dose will be 1-2 nmol daily. Effective dosing in preclinical research represents doses at 5-10 nmol a day to perform neuroendocrine research and metabolical modulation. The maximum safe dose for experimentation, no entanto, is 15 nmol a day to avoid too much stimulation of KISS1 receptor and interference with hormonal balance and metabolism.
3.3 Managing Missed Doses
The missed doses are not compensated in accordance with laboratory standards since proper record keeping is sufficient to manage skipped doses. It is necessary to keep records of doses that have been missed during the experiment to maintain cycles, and compensate for any discrepancies accordingly. It is forbidden to over-dose compensatorily since that will create problems with hormone levels.
- Dosage Forms
The sole dosage form here is a lyophilized peptide powder that requires to be dissolved in sterile bacteriostatic water since there are no methods of manufacturing oral forms.
- Status with FDA
Kisspeptin is an investigational research peptide according to the FDA classification, which means it has not been approved for clinical use. This peptide is banned from commercialization and individual administration.
10 Common FAQs About Peptides
- What is a peptide?
Answer: A peptide is a short chain of amino acids linked together by peptide bonds. It is smaller and more easily absorbed by the human body than proteins, serving as a fundamental functional substance in biological organisms.
- What is the difference between peptides and proteins?
Answer: The core difference lies in molecular length and structure. Peptides are short amino acid chains (usually consisting of 2–50 amino acids), while proteins are long, complex amino acid chains with stable three-dimensional structures. Peptides have stronger permeability and faster absorption efficiency than proteins.
- What are the main types of peptides?
Answer: Peptides are mainly classified by the number of amino acids: dipeptides, tripeptides, oligopeptides (2–10 amino acids) and polypeptides (10–50 amino acids). They can also be divided into natural peptides and synthetic peptides according to their sources.
- What are the biological functions of peptides?
Answer: Peptides have diverse biological activities, including regulating human metabolism, improving immune function, promoting cell repair, anti-oxidation, anti-aging, and adjusting hormone levels. They act as key signaling molecules and regulatory factors in the body.
- Are peptides safe for human use?
Answer: Most natural and medically approved synthetic peptides are highly safe. They have small molecular weight, low toxicity, and will not accumulate in the body. However, unstandardized high-dose peptide products or impure synthetic peptides may cause mild discomfort.
- What are the common applications of peptides?
Answer: Peptides are widely used in multiple fields. In biomedicine, they are made into therapeutic drugs for endocrine and immune diseases; in cosmetics, they are used for anti-aging and skin repair; in health products, they serve as nutritional supplements to improve physical fitness.
- Can the human body absorb exogenous peptides directly?
Answer: Yes. Unlike proteins that need to be decomposed before absorption, small-molecule peptides can be directly absorbed by the intestinal tract and skin with high absorption rate and utilization efficiency, and can quickly exert biological effects in the body.
- What are synthetic peptides used for?
Answer: Synthetic peptides are artificially customized amino acid chains. They are mainly used for scientific research, clinical drug development, targeted skin care ingredient production, and precise nutritional supplementation, with higher purity and targeted activity than some natural peptides.
- Do peptide products have side effects?
Answer: Standard peptide products have almost no obvious side effects for most people. Individual groups may experience mild gastrointestinal discomfort or skin sensitivity due to physical differences or excessive intake. Long-term excessive use may disrupt the body’s metabolic balance.
- What is the difference between collagen peptides and ordinary peptides?
Answer: Collagen peptides are a specific type of functional peptide extracted and decomposed from collagen, mainly targeting skin moisturizing, anti-wrinkle and joint care. Ordinary peptides cover a broader range with more diverse regulatory functions including immunity and metabolism, while collagen peptides have more focused skincare and anti-aging effects.
All of our fiber optic cable package are with export wooden drum. Indoor FTTH cable’s wooden dimension is 50x50x32cm, delivery length 3km/drum, Outdoor fiber optic cable’s wooden dimension is 110cm*110cm*70cm, 0.85CBM, can be load about 33 drums for a 20GP.Also accept custom cable drum from customers. welcome to contact us!
GYTS Direct Burial Single Armored Double Sheath Fiber Optic Cable
GYTS Fiber Optic Cable Picture
Shipping Choice |
| Shipping method | Courier | Shipping Time |
| Express Shipping | UPS | 5-15 DAY |
| Fedex | 5-15 DAY |
| Dedicated line | USPS | 7-15 DAY |
| Fedex | 7-15 DAY |
| DDP | | 10-20 DAY |
Powerae.com
